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Sunday, September 30, 2012
Eva Longoria All White Fashion Fail!
Eva Longoria showed up to a very worthy event, one that should earn her respect. With that said, her choice of a gown is just plain embarrassing. It was an epic fail! This column obviously has no filter to it. We’ve made fun of the elderly, the young and clueless, the intoxicated, and of course, the ridiculously wealthy. Well this time around it’s no different. We have set our sites on the former star of Desperate Housewives, who showed up to an event looking like something that was plucked off of the top of a wedding cake. Usually she is understated, but not really conservative. Back when her show was at the top of the ratings, she would go to events dressed to the nines. This time, she looks just simple and plain. Take a look at a gallery of her at the 12th Annual Padres Contra El Cancer’s “El Sueno De Esperanza” and judge for yourself. Pictures: PR Photos
Studies show drug combinations effective for melanoma
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Public release date: 29-Sep-2012[ | E-mail |
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European Society for Medical Oncology
Promising new data from trials aimed at delaying resistance to BRAF inhibitors
Vienna, Austria, 29 September 2012 - Promising new data on drug combinations to treat metastatic melanoma are presented at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.
The phase I and II trials focus on combining drugs to slow the development of resistance to drugs that inhibit BRAF, a gene that is mutated in about half of melanomas. Earlier trials with drugs that target BRAF generated excitement for their ability to quickly shrink melanoma tumors in suitable patients. But for many patients the benefits proved short-lived, as the cancer cells develop resistance to the drugs.
"These studies exemplify an important landmark of some tumors, which has emerged from recent laboratory research: the presence of specific mutations, such as the BRAF mutation in metastatic melanoma which exposes an Achilles' heel--MEK in this case," said Prof Yossef Yarden from the Weizmann Institute of Science, Israel. "In-depth understanding of cancers and their mutations is expected to reveal more of these deadly weaknesses in cancer, which we can exploit using new drugs and drug combinations."
Phase II of the BRAF inhibitor dabrafenib alone vs combination with MEK1/2 inhibitor trametinib
Dr Georgina Long from Westmead Hospital and the Melanoma Institute Australia and colleagues report that combining the new drugs dabrafenib and trametinib provided a clinically meaningful improvement in progression-free survival, response rate and duration of response in 162 patients with melanoma that had BRAF V600 mutations.
Patients in the study received either dabrafenib 150mg twice daily; twice-daily dabrafenib plus once-daily 1mg trametinib; or twice daily dabrafenib plus once-daily 2mg trametinib. The combination prolonged progresion free survival over single-drug therapy from 5.8 months to 9.4 months, which represents a 60% improvement. Among patients who received both drugs at the higher dose, 41% had not progressed 12 months after treatment began, compared to 9% in the monotherapy arm of the study.
"The combination therapy of the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib prolongs the progression-free survival in patients with V600 BRAF mutation-positive metastatic melanoma compared with dabrafenic monotherapy," Dr Long said. "Importantly, the combination also decreases the rate of the cutaneous toxicities compared with dabrafenib monotherapy, particularly the oncogenic cutaneous toxicity of squamous cell carcinoma."
Phase IB study of vemurafenib in combination with the MEK inhibitor, GDC-0973
A Phase I study in 44 patients shows that the combination of the MEK inhibitor GDC-0973 and vemurafenib can be delivered safely, Dr Rene Gonzalez of the University of Colorado Cancer Center, Denver, and colleagues report.
"BRAF inhibition has resulted in high response rates and improved survival in patients with BRAF mutated melanoma," Dr Gonzalez said. "One of several mechanisms of resistance has been reactivation of the MAPK pathway. Preclinical models show that combined inhibition of BRAF and MEK can delay the acqusition of resistance compared to BRAF inhibitor monotherapy. Inhibition of the pathway downstream from BRAF with the MEK inhibitor GDC-0973 could theoretically overcome or delay this resistance mechanism and improve outcomes."
The study was not designed to evalate efficacy. "While early data in a small number of patients did show tumor reduction, it would be premature to comment on efficacy based on these preliminary results and further research is warranted," Dr Gonzalez said.
###
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 29-Sep-2012[ | E-mail |
Share ] Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology
Promising new data from trials aimed at delaying resistance to BRAF inhibitors
Vienna, Austria, 29 September 2012 - Promising new data on drug combinations to treat metastatic melanoma are presented at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.
The phase I and II trials focus on combining drugs to slow the development of resistance to drugs that inhibit BRAF, a gene that is mutated in about half of melanomas. Earlier trials with drugs that target BRAF generated excitement for their ability to quickly shrink melanoma tumors in suitable patients. But for many patients the benefits proved short-lived, as the cancer cells develop resistance to the drugs.
"These studies exemplify an important landmark of some tumors, which has emerged from recent laboratory research: the presence of specific mutations, such as the BRAF mutation in metastatic melanoma which exposes an Achilles' heel--MEK in this case," said Prof Yossef Yarden from the Weizmann Institute of Science, Israel. "In-depth understanding of cancers and their mutations is expected to reveal more of these deadly weaknesses in cancer, which we can exploit using new drugs and drug combinations."
Phase II of the BRAF inhibitor dabrafenib alone vs combination with MEK1/2 inhibitor trametinib
Dr Georgina Long from Westmead Hospital and the Melanoma Institute Australia and colleagues report that combining the new drugs dabrafenib and trametinib provided a clinically meaningful improvement in progression-free survival, response rate and duration of response in 162 patients with melanoma that had BRAF V600 mutations.
Patients in the study received either dabrafenib 150mg twice daily; twice-daily dabrafenib plus once-daily 1mg trametinib; or twice daily dabrafenib plus once-daily 2mg trametinib. The combination prolonged progresion free survival over single-drug therapy from 5.8 months to 9.4 months, which represents a 60% improvement. Among patients who received both drugs at the higher dose, 41% had not progressed 12 months after treatment began, compared to 9% in the monotherapy arm of the study.
"The combination therapy of the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib prolongs the progression-free survival in patients with V600 BRAF mutation-positive metastatic melanoma compared with dabrafenic monotherapy," Dr Long said. "Importantly, the combination also decreases the rate of the cutaneous toxicities compared with dabrafenib monotherapy, particularly the oncogenic cutaneous toxicity of squamous cell carcinoma."
Phase IB study of vemurafenib in combination with the MEK inhibitor, GDC-0973
A Phase I study in 44 patients shows that the combination of the MEK inhibitor GDC-0973 and vemurafenib can be delivered safely, Dr Rene Gonzalez of the University of Colorado Cancer Center, Denver, and colleagues report.
"BRAF inhibition has resulted in high response rates and improved survival in patients with BRAF mutated melanoma," Dr Gonzalez said. "One of several mechanisms of resistance has been reactivation of the MAPK pathway. Preclinical models show that combined inhibition of BRAF and MEK can delay the acqusition of resistance compared to BRAF inhibitor monotherapy. Inhibition of the pathway downstream from BRAF with the MEK inhibitor GDC-0973 could theoretically overcome or delay this resistance mechanism and improve outcomes."
The study was not designed to evalate efficacy. "While early data in a small number of patients did show tumor reduction, it would be premature to comment on efficacy based on these preliminary results and further research is warranted," Dr Gonzalez said.
###
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-09/esfm-ssd092712.php
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Los Angeles drivers see minimal traffic in "Carmageddon 2"
LOS ANGELES (Reuters) - Drivers in Los Angeles saw limited congestion on Saturday near a key freeway corridor shut down this weekend in what has been dubbed "Carmageddon 2," due to fears of gridlock from a 53-hour construction project, officials said.
A 10-mile (16-km) stretch of the 405 Freeway at the Sepulveda Pass, normally the nation's busiest thoroughfare, was closed at midnight on Friday for a $1 billion freeway widening project.
But so far, despite the slowing near the project itself, traffic seemed to be zipping along in the city as a whole, said California Highway Patrol spokeswoman Officer Charmaine Fajardo.
"So far so good, it looks like people are heeding the information we've put out there and staying out of the area," Fajardo said.
Construction crews with giant cranes on Saturday chipped away at a bridge spanning the 405 Freeway in the city, with pieces of concrete dropping dozens of feet (meters) to the ground below. A four-foot (1.2-metre) pad of dirt laid down in advance protected the pavement from the falling debris.
The work is to widen the bridge itself to expand the freeway below.
The project comes just over a year after a similar weekend construction shut down the same area in what was dubbed "Carmageddon," in anticipation of massive congestion that never came to pass as many drivers stayed home.
This year, the project has caused some anxiety nonetheless among officials and motorists in the city where car travel is king but only very limited congestion had materialized by noon.
More significant delays could develop on Saturday afternoon as people pile into cars heading for the beach, highway patrol officials said.
The shutdown of the 405 Freeway along the Sepulveda Pass is scheduled to end at 5 a.m. on Monday, said Marc Littman, a spokesman for the Metropolitan Transportation Authority.
The construction crew on the project stands to be fined $6,000 per closed lane for every 10 minutes that the project extends past its scheduled ending on Monday morning, officials said. (Reporting by Alex Dobuzinskis; Editing by Colleen Jenkins and Sandra Maler)
Source: http://news.yahoo.com/los-angeles-drivers-see-minimal-traffic-carmageddon-2-192613668--sector.html
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Saturday, September 29, 2012
Iraqi officials say jailbreak assisted from inside
BAGHDAD (AP) ? Iraqi officials said Saturday that a jailbreak where al-Qaida-linked militants escaped death row had help from inside, further tarnishing state authority and raising new concerns over corruption.
A day after the escape in Tikrit, Saddam Hussein's hometown 130 kilometers (80 miles) north of Baghdad, scores of prisoners are still at large.
The Interior Ministry said there had been "clear collusion" between some guards and inmates in the Tasfirat prison. Weapons were brought in during family visits, and wardens left locks inside the facility open.
"The cells were not searched for a long period, which indicates more deliberate negligence that led to this incident," the ministry said in a statement released late Friday.
The escape occurred after a riot and firefight that left 20 dead, including 16 inmates and four guards, the statement said. After taking over a large part of the prison, rioters used other inmates as human shields in order to make their way out, it added. Of a total 303 prisoners, 102 escaped, including 47 al-Qaida-linked inmates awaiting execution. Some 23 were recaptured.
On Saturday, state television announced a reward for information leading to the arrest of the fugitives, and a curfew remained in force until the afternoon. Salahuddin provincial spokesman Mohammed al-Assi said "security forces have intensified efforts to hunt down those still on the run."
He refused to say how much the reward is for.
The incident generated sharp criticism for Iraqi security forces, who have been unable to stabilize the country almost a year after the withdrawal of U.S. troops. Several smaller escapes and attempted jailbreaks have already deeply embarrassed the government, which is eager to demonstrate it can run its justice and detention systems.
The Interior Ministry statement also said that Maj. Gen. Abdul-Karim al-Khazraji, the police chief of Salahuddin province where the jailbreak occurred, was fired.
Iraq has a poor track record of keeping inmates behind bars.
The Tikrit prison itself was moved to a different location after 16 prisoners, including five al-Qaida-linked inmates awaiting execution, made their escape after prying open the bars on a prison bathroom window with a pipe wrench in September 2009.
At the time, the entire prison staff and the provincial prison official were detained for questioning. Six of the escaped inmates were later captured.
And in southern city of Basra, a dozen detainees held on terrorism charges broke out of a prison in 2010, disguised in police uniforms. And last year, al-Qaida smuggled weapons and grenades into a prison in Mosul, supposedly one of the country's most secure detention centers, and attempted an ultimately unsuccessful jailbreak that left 17 dead.
In July 2011, detainees linked to al-Qaida escaped at least twice from a Baghdad area prison known as Camp Cropper shortly after the U.S. handed it over to Iraqi authorities.
Authorities earlier reported 12 people dead and 32 wounded in Friday's break in Tikrit.
___
Associated Press writer Sameer N. Yacoub contributed to this report.
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Omar Khadr now back in Canada from Guant?namo
The United States sent Guant?namo?s youngest captive home to a prison in his native Canada on Saturday, ending the decade-long U.S. detention of the Muslim militant who grew from a teenager into adulthood at the Pentagon?s prison camps in Cuba.
In 2002, at age 15, Omar Khadr hurled a grenade in war-torn Afghanistan that killed an American soldier. He was captured and kept by U.S. forces ever since. Now 26, he?s home and could serve up to six more years in a Canadian prison. Or authorities could release him sooner. Canada considers him a juvenile offender who can apply for parole a year from now.
?He thinks he?s in a dream. He?s pinching himself,? said Toronto attorney John Norris, who spoke to Khadr soon after his arrival. ?He never believed this day would come; he?s been betrayed so many times before.?
Khadr departed the base in Cuba before dawn Saturday, a secret transfer 10 days after a Canadian diplomat paid Khadr a visit on his 26th birthday. He landed at a Royal Canadian airbase in Ontario and was transferred to the Millhaven maximum security prison for what his lawyer described as an assessment of the most suitable place to serve out his sentence.
The case of Khadr ? Guant?namo?s last Western captive ? stirred debate in international law and human rights circles.
Because he was captured at such a young age, some called him a child soldier who was dropped off in the war zone by his father and deserving of rehabilitation not interrogation. Others called him the respected scion of an al Qaida family, nicknamed Canada?s First Family of Terror in news reports, and opposed his repatriation.
Psychiatrist Michael Welner, testifying at the Guant?namo war court for the prosecution and paid by the Pentagon, called Khadr a continuing danger who spent his time at the U.S. prison camps in Cuba ?marinating in a community of hardened and belligerent radical Islamists.?
Khadr?s lawyers offered up tales of abusive treatment in U.S. custody. He?d been questioned in Afghanistan while emerging from surgical anesthesia, they argued. He was used as a ?human mop? at Guant?namo after he urinated on himself and the floor during an interrogation. His lawyer was forbidden from seeing him during his first two years of interrogations.
U.S. troops captured Khadr, who was near death, in a July 27, 2002 firefight at a suspected al Qaida compound near Khost, Afghanistan.
U.S. air strikes had leveled the compound and as a Special Forces unit assaulted, Khadr admitted in a 2010 guilty plea, he threw a grenade from the rubble that mortally wounded Army Sgt. 1st Class Christopher Speer, 28. Medics were able to save Khadr?s life and turned him over to what became a decade of on-again off-again interrogation.
Since his conviction, he was confined to a maximum-security wing at Guant?namo, a mostly solitary existence that his lawyers tried to ameliorate with a Canadian-style college preparatory curriculum ? literature, physics and videos of ?Little Mosque on the Prairie,? a popular Canadian TV show about a Muslim community in a fictional prairie town.
He also read Shakespeare with his U.S. defense lawyer, Army Lt. Col. Jon Jackson, who played Juliet to Khadr?s Romeo.
Source: http://www.miamiherald.com/2012/09/29/3025662/omar-khadr-repatriated-to-canada.html
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Auction of $7 Renoir canceled, may be stolen from Baltimore museum
WASHINGTON (Reuters) - A Virginia auction house on Thursday canceled the sale of a Renoir painting bought at a flea market for $7 after signs the work was stolen from the Baltimore Museum of Art decades ago.
The painting "Paysage Bords de Seine" by Pierre-Auguste Renoir was to have gone under the hammer on Saturday but ownership questions halted the sale, said Lucie Holland, a spokeswoman for Potomack Co, the Alexandria, Virginia, auctioneer.
"The rest of the auction will go on, but the Renoir has been withdrawn," she said.
A Virginia woman bought the signed French Impressionist painting at a West Virginia flea market a year or two ago, hoping the frame would be of some use.
She ignored the work until it turned up again while housecleaning and had it appraised by Potomack in July. The auctioneers verified it as a Renoir and estimated its worth at $75,000 to $100,000.
The Baltimore Museum of Art told Potomack on Wednesday that its records indicated "Paysage Bords de Seine," or "Landscape on the Banks of the Seine," was stolen while on loan to the museum in 1951, the auction house said.
Potomack told the FBI and a federal probe is under way. There is no known police report on the theft.
BOUGHT IN PARIS
The Renoir came to the Baltimore museum through one of its leading benefactors, collector Saidie May. Her family bought the painting from the Bernheim-Jeune gallery in Paris in 1926.
The Washington Post found records in the museum's library on Tuesday that showed May had lent the paintings and other works to the museum in 1937, Potomack said.
After the newspaper told it of the findings, the Baltimore museum checked its files and found a loan record showing the Renoir had been stolen on November 17, 1951. What happened to it after the theft is unknown.
Doreen Bolger, the museum director, said the museum's probe into what happened to the painting was in early stages but was centered on May.
She died in May 1951 and the art collection was willed to the museum. As its ownership was going through legal transfer, the painting was stolen while still listed as on loan.
"At this point we just want to make sure that the painting winds up where it belongs and that we provide all the information we can to law enforcement about this issue," Bolger said.
Potomack said the painting had not turned up when it checked London's Art Loss Register, a database of stolen and lost art. It also consulted the FBI's art theft website to confirm it was not listed as stolen.
(Editing by Mohammad Zargham)
Source: http://news.yahoo.com/auction-7-renoir-canceled-may-stolen-baltimore-museum-015102740.html
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Further Renovations of Sports and Recreation ... - Management Blog
Dear Members,
I would like to take this blog entry to inform you of some important announcements for further renovations and maintenance around the Sports and Recreation facilities.
The 3/F Swimming Pool will be closed from October 8 to 24.? As well as the installation of the bubble, we will carry out essential maintenance. During this period the G/F Tropical Pool will be open from 7am to 10.30pm daily.
North Shore Tennis Court will be renovated from mid November to mid January and one court will be kept open for Members.
Prior to the closure of the 3/F Swimming Pool as mentioned above I would like to remind you that our Annual Swim Gala will take place on Sunday, October 7 from 1pm to 4pm.
The Bowling Alley renovation is scheduled to be ready towards the latter part of October and we are also looking forward to introducing a new Table Tennis room on the 7/F in the coming weeks.
Please also look out for our new group exercise classes that we will be introducing in the near future such as Fitball and ViPR (Vitality, Performance and Reconditioning).
Best regards,
Derek
Director of Sports and Recreation
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Friday, September 28, 2012
At Google HQ, Calif. Gov. Jerry Brown signs self-driving cars bill
The bill by Democratic Sen. Alex Padilla will establish safety and performance regulations to test and operateautonomous?vehicles on state roads and highways.
California Gov. Edmund G Brown Jr. (c.) hands his pen to Google co-founder Sergey Brin (r.) after a bill signing for driverless cars at Google headquarters as state Senator Alex Padilla (l.) looks on in Mountain View, Calif., Sept. 25. The legislation will open the way for driverless cars in the state. Google, which has been developing autonomous car technology and lobbying for the legislation has a fleet of driverless cars that has logged more than 300,000 miles (482,780 kilometers) of self-driving on California roads.
Eric Risberg/AP
EnlargeMOUNTAIN VIEW, California
Gov. Jerry Brown rode to Google headquarters in a self-driving Toyota Prius before signing legislation Tuesday that will pave the way for driverless?cars?in California.
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The bill by Democratic Sen. Alex Padilla will establish safety and performance regulations to test and operateautonomous?vehicles on state roads and highways.
"Today we're looking at science fiction becoming tomorrow's reality ? the self-driving?car," Brown said. "Anyone who gets inside a?car?and finds out the?car?is driving will be a little skittish, but they'll get over it."
Google has been developing?autonomous?car?technology and lobbying for the regulations. The company's fleet of a dozen computer-controlled vehicles has logged more than 300,000 miles (483,000 kilometers) of self-driving without an accident, according to Google.
"I think the self-driving?car?can really dramatically improve the quality of life for everyone," Google co-founder Sergey Brin said.
Autonomous?cars?can make roads safer, free commuters from the drudgery of driving, reduce congestion and provide transport to people who can't drive themselves, such as the blind, disabled, elderly and intoxicated, Brin said.
"I expect that self-driving?cars?will be far safer than human-driven?cars," Brin said.
Brin predicted that?autonomous?vehicles will be commercially available within a decade. He said Google has no plans to produce its own?cars, but instead plans to partner with the automobile industry to developautonomous?vehicles.
The Alliance of Automobile Manufacturers expressed concern that California is moving too quickly to embrace self-driving?cars?and needs to first sort out liability issues.
"Unfortunately this legislation lacks any provision protecting an automaker whose?car?is converted to anautonomous?operation vehicle without the consent or even knowledge of that auto manufacturer," the trade group said in a statement.
Autonomous?cars?use computers, sensors and other technology to operate independently, but a human driver can override the autopilot function and take control of the vehicle at any time.
With smartphone-wielding drivers more distracted than ever, backers say robotic vehicles have the potential to significantly reduce collisions and traffic fatalities, noting that nearly all?car?accidents are a result of human error.
The legislation requires the California Department of Motor Vehicles to draft regulations for?autonomousvehicles by Jan. 1, 2015. Currently, state law doesn't mention self-driving?cars?because the technology is so new.
The regulations would allow vehicles to operate?autonomously, but a licensed driver would still need to sit behind the wheel to serve as a backup operator in case of emergency.
The legislation also is aimed at keeping California at the forefront of the?autonomous?car?industry since Stanford University and Silicon Valley companies have been working on the technology for years.
In February, Nevada became the first U.S. state to approve regulations spelling out requirements for companies to test driverless?cars?on that state's roads.
Carmakers such as Audi AG, BMW AG, Ford Motor Co. and Volvo have been working on?autonomous?cartechnology for years.
In recent years, automakers also have been introducing?autonomous?functions such as self-parking, lane departure warnings and adaptive cruise-control, which allows vehicles to automatically accelerate and decelerate with the flow of traffic.
Outside a cafe in Mountain View, California, customers said they looked forward to a day when their?cars?could drive themselves, as long as they could do it safely.
"It would make our streets safer," said Barrett Howard, 33, an auto technician. "We wouldn't have to worry about people texting or getting sidetracked. The computer will take over, and it will make life easier."
Abraham Eshel, a retired mechanical engineer who has vision problems, said self-driving?cars?would make his life easier, too.
"If I could tell my?car, 'OK, you take over when it's dark,' and I don't have to worry about it, that would be fantastic," said Eshel, who lives in nearby Los Altos. "It's a good idea. Why not make progress if it's possible?"
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Don't mind the zero-emissions Mercedes fuel-cell car behind the invisible curtain (eyes-on video)
Mercedes wanted to make a dramatic statement about how its new B-Class F-Cell car passes through the environment without leaving a trace, so it placed it behind an invisible LED curtain. We wanted to (not?) see that for ourselves at the Paris Auto Show, so took a quick tour of the magic LED cloak and the technology behind it. It doesn't work quite as well in a show hall as it did when we first saw it in its natural habitat, but the system was still a fun way to show off Merc's green ambitions. It works by passing video from behind the car taken with a Sony video camera through a laptop to a 200 x 300 resolution LED curtain. That makes the car blend in with its background, which is what such a car would do in the real world as far as its emissions go -- apart from a little water, of course. See the video below for the complete technical explanation.
Filed under: Transportation
Don't mind the zero-emissions Mercedes fuel-cell car behind the invisible curtain (eyes-on video) originally appeared on Engadget on Fri, 28 Sep 2012 11:51:00 EDT. Please see our terms for use of feeds.
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Excellent Pointers To Boost Your Social Media Marketing ...
If you want to advertise any business online, particularly yours, social media marketing is the tool that you must use. Many business owners, however, are not sure how set up their campaigns, how to target their chosen audience, or how to optimize their marketing budget. The following advice will help you make the most of social media marketing.
Be careful if you are considering using a marketing company for social media. A lot of these companies are dishonest and scam business owners. Thoroughly research any type of social media marketing company you are considering hiring to manage your campaign. Your ads will be seen by their fake accounts to ramp up the numbers, while you get no profit from your investment.
TIP! The advertisements on social media are often well thought out and customized images manipulated in Photoshop. Think of the images you use in this application as magnets that you have specially designed to draw the viewer?s eyes to your ad.
Pay attention to the spikes in traffic each time you apply a different social media technique, and carefully analyze the results. It is important that you not jump to conclusions because you having a very good or bad day. But it is imperative that you can see trends and anticipate your actions based on them.
Try buying some advertising on social networking sites. This type of advertising is not expensive; in addition, it is targeted advertising that goes only to customers that use appropriate keywords. Facebook and MySpace are two networks that offer such tools.
Twitter is a powerful social networking platform that can be a valuable promotional tool for your business. If you study how to use Twitter and what it can do for you, you can get hundreds of thousands of people to see your products. Research the tools provided by Twitter, including keywords and hashtags.
TIP! To make a more friendly site that works with social media, try adding comments, ratings, and a way to sort material. These functions allow customers to personalize their visit to your site.
You need to share your content whenever possible. You will have to write quality articles and post them on your social networks. Consider putting content on some sites such as HubPages or Associate Content using your name. If need be, hire others to either compose fresh or recycled content.
Make it easy for people to subscribe to your bog. Don?t hide the subscribe button somewhere that no one will see it. Ideally, it should be positioned in a prominent location. Remember that some customers have different Internet speeds, so make sure the button loads easily.
If you?re not renown for your formatting abilities, think about posting your next article as a list in social media updates. That way, all your information can be concisely presented in order of importance. Younger users, in particular, seem to favor information that gets right to the point and doesn?t include a lot of extra verbage.
TIP! YouTube is an excellent mechanism for marketing your business. Regularly create videos about new business activities, or create an ongoing video blog.
You need to understand your audience in order to figure out how to market on social media networks. You need to find out what these people are using social networks for, how much time they are spending on this type of website and what kind of content they would like to see.
You can effectively create publicity by hosting a contest on Facebook, Twitter or an other social media site. Choose some prizes that will be of interest to your audience to encourage people to enter the contest. Due to the way online social networks operate, information about your contest will rapidly spread. Be sure that it is creative, entertaining, and has something to do with what you?re selling. A good contest example would be to see who can come up with the best logo for a future product you are putting out.
Be sure to think of eye-catching headings for your posts. Your reader makes a first impression based on your headline. If it is catchy, they are more likely to read the article. Put some real effort into good headlines.
TIP! Host employee blogs and feature them on your website to attract potential customers. Through these blogs, your customers will get an inside look at the inner workings of your business.
Share information about your business on social media sites. Write about your latest innovations, your involvement with your community or share pictures of your products and your store. Post about employees or show photos of them working. Use whatever you can to show your company in a positive light.
The information that you have just read should lead you to feel more confident in your ability to develop a powerful social media marketing strategy. Keep in mind when you market effectively, you give yourself the opportunity to gain more followers and customers for your business every year.
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Thursday, September 27, 2012
'Sons of Anarchy' Creator Kurt Sutter ?Not Shocked? By Johnny ...
Frederick M. Brown, Getty Images / FX
Earlier this morning, tragic and surprising news broke that one-time ?Sons of Anarchy? star Johnny Lewis had died in a bizarre incident where the actor beat his 81-year-old landlady to death, got in an altercation with several men and died in a fall from the home in which he?d rented a room. Though the investigation is still on-going, ?Sons of Ancarhy? creator Kurt Sutter has issued his own response to the news, for which he grieves, but claims not to be surprised by.
While the ?Sons of Anarchy? cast and crew, as well as the family, friends and fans of actor Johnny Lewis continue to grieve for his death, series creator and Lewis? one-time boss Kurt Sutter had some unique words regarding the man?s passing. Taking to his Twitter account, Sutter explained that while Lewis? loss was tragic, it was not unforeseen.
not sure if folks know this yet, but johnny lewis (halfsack) died last night.? the sad irony of it happening two days after Opie?s death is not lost on me. it was a tragic end for an extremely talented guy, who unfortunately had lost his way. i wish i could say that i was shocked by the events last night, but i was not.
i am deeply sorry that an innocent life had to be thrown into his destructive path. yes, it?s [a] day [of] mourning, but it?s also a day of awareness and gratitude. sadly, some of us carry the message by dying.
Sutter refers to the ?irony? of recent headlines surrounding ?Sons of Anarchy,? in which a beloved on-screen character and member of the SAMCRO organization was shockingly killed off. In real life, Lewis himself portrayed Kip ?Half-Sack? Epps on the series for the first two seasons, before the character was killed off at Lewis? request. Reportedly, Lewis had ?creative differences? with Sutter, and wished to be let go from his contract.
Sutter likely has a great deal of insight into the actor?s demise, in which police are investigating claims that the actor was on drugs at the time of his death, and facing a number of recent criminal charges.
Elsewhere, the investigation continues into the tragic loss.
Source: http://screencrush.com/sons-of-anarchy-johnny-lewis-kurt-sutter/
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North and South Carolina REALTORS? ?ComeTogether? for annual ...
COLUMBIA, S.C. ? September 27, 2012 ? (RealEstateRama) ? North and South Carolina REALTORS? (SCR) joint Annual Conference and Expo, ComeTogether, was a big success with more than 700 REALTORS? from across both states in attendance. The event was held at the Savannah International Trade and Convention Center, September 9-11. Highlights of the conference are listed below. Photos and interviews are available upon request.
2013 President
Incoming SCR President, Alexander ?Sandy? Stone III, of the Charleston Trident Association of REALTORS? was inducted by outgoing SCR President, Gordon Seay of the Greater Greenville Association of REALTORS?. Stone?s term as SCR President begins in November 2012.
2012 REALTOR? of the Year
Charleston REALTOR? Nell Postell was named SCR?s 2012 REALTOR? of the Year in a touching ceremony during the Opening General Session of the conference. Postell has been a leader in real estate for thirty years and currently practices at Carolina One Real Estate in Charleston, South Carolina. A video tribute to Postell is available via SCR?s YouTube channel.
Distinguished Service Award
Jeff Bowers has contributed more than 26 years of outstanding service to the real estate industry. Throughout that time he has been a past president of the South Carolina Certified Residential Specialist (CRS) Chapter, past president of Dorchester Habitat for Humanity and is one of Charleston?s top 10 real estate agents. Bowers is currently broker and owner at RE/MAX Pro Realty in Charleston and the 2012 recipient of SCR?s Distinguished Service Award.
Omega Tau Rho Medallion of Honor
Membership in this honorary fraternity is represented by the Medallion of Service which symbolizes the recognition and appreciation of accorded inductees for their contributions to the Nation Association of REALTORS? (NAR), its affiliated institutes, societies and councils. The 2012 Medallion was presented to Greater Greenville Association Executive, Nick Sabatine for his exemplary direction and guidance to REALTORS? throughout the Upstate.
C. Dan Joyner REALTOR? Community Service Award
Mt. Pleasant REALTOR? Mia Owens is the 2012 recipients of the C. Dan Joyner Community Service Award. Owens won the award for her work on Feed a Friend ? a charity created to help feed the homeless and working poor. To-date Owens has served more than 2,000 people throughout the area. Winners of this award are also entered into the National Association of REALTORS?? Good Neighbor Award contest.
James R. Peters Association Executive Award of Excellence
The James R. Peters Association Executive Award of Excellence is presented annually to an individual who has excelled in their role as an executive of a local South Carolina REALTOR? association. Peggy Hill, Association Executive of the Western Upstate Association of REALTORS? received the award for the countless hours she has dedicated to the local, state and national associations. Hill also devotes her time to many community groups including the Anderson Area Chamber of Commerce, Anderson Rotary and the YMCA Strong Kids Campaign.
REALTOR? Advocate Award
The South Carolina REALTOR? Advocate Award is given annually to a member who demonstrates a constant effort and unwavering commitment as an advocate for the real estate industry. This year?s recipient, Greenwood REALTOR?, Jerry Spearman, has tirelessly served as a real estate advocate at the South Carolina Statehouse. Spearman truly recognizes the importance of taking an active role in advocacy and raising awareness of issues at the grassroots level.
W. Mack Chamblee Quality of Life Award
The South Carolina REALTORS? give the W. Mack Chamblee Quality of Life Award each year to members of the General Assembly who demonstrate themselves as leaders in promoting and protecting quality of life in South Carolina. The South Carolina REALTORS? awarded Senator Paul Campbell of Goose Creek and Speaker Bobby Harrell of Charleston with the 2012 W. Mack Chamblee Quality of Life Awards.
Education Sessions
ComeTogether offered many education sessions at the conference including courses on technology and popular real estate topics. The highlight of the education courses was a BarCamp style session in which the attendees were also instructors in breakout brainstorming sessions. Seasoned real estate veterans exchanged their valuable experiences with rookie tech-savvy REALTORS? in a meeting of the minds.
###
South Carolina REALTORS? (SCR) is the largest professional trade association in the state, serving as the voice of real estate for more than 14,000 members involved in all aspects of the residential and commercial real estate industries. REALTOR? is a registered trademark that identifies a professional in real estate who subscribes to a strict code of ethics as a member of SCR and the National Association of REALTORS?.
REALTOR? is a federally registered collective membership mark which identifies a real estate professional who is a Member of the National Association of REALTORS? and subscribes to its strict Code of Ethics. This email and any files sent with it are confidential. If you have received this email in error, please notify the sender and then delete it immediately.
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Mini Couture: Blue Ivy?s Custom Ruthie Davis Sneakers
Beyonce and Jay-Z's daughter just added a sparkly pair of Ruthie Davis sneakers to her shoe collection.
Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/d6tTCa07SB4/
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Wednesday, September 26, 2012
Police seal off Spain Parliament ahead of protest
MADRID (AP) ? Spain's Parliament took on the appearance of a heavily guarded fortress Tuesday, hours ahead of a protest against the conservative government's handling of the economic crisis.
The demonstration, organized behind the slogan 'Occupy Congress,' is expected to draw thousands of people from around Spain and was due to start around 1730 GMT.
Madrid's regional Interior Ministry delegation said some 1,300 police would be deployed though protesters say they have no intention of storming the chamber, only of marching around it.
They are calling for fresh elections, claiming the government's austerity measures show the ruling Popular Party misled voters to get elected last November.
The protest comes as Spain struggles in its second recession in three years and with unemployment near 25 percent.
Spain has introduced austerity measures and economic reforms in a bid to convince its euro partners and investors that it is serious about reducing its bloated deficit to 6.3 percent of gross domestic product in 2012 and 4.5 percent next year.
Concerns over the country's public finances was evident earlier when the Treasury sold ?3.98 billion ($5.14 billion) in short-term debt but at a higher cost.
It sold ?1.39 billion in three-month bills at an average interest rate of 1.2 percent, up from 0.95 percent in the last such auction Aug. 28, and ?2.58 billion in six-month bills on a yield of 2.21 percent, up from 2.03 percent.
The government is expected to present a new batch of reforms Thursday as it unveils a draft budget for 2013. A day later the results of bank stress tests carried out by an international auditing company are to be released.
Spain has already been granted a ?100 billion loan by its 16 partner nations using the euro currency to help bail out those of its banks worst hit by the collapse of the country's real estate sector in 2008.
Spain has yet to tap the fund and initial estimates say the banks will need some ?60 billion.
Source: http://news.yahoo.com/police-seal-off-spain-parliament-ahead-protest-073010461.html
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Police seal off Spain Parliament ahead of protest
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Google Brings Its Indoor Maps To France
Google today announced that it is bringing its indoor maps for places like airports, museums, and malls in Google Maps for Android to France. So the next time you stop by Galeries Lafayette in Paris, you will be able to see detailed floor plans for every floor, including information about escalators, ATMs and nearby restrooms. The maps vary in detail, but the floor plans for supermarket chain Carrefour, for example, will even show you what's in the different aisles and give you walking directions.Source: http://feedproxy.google.com/~r/Techcrunch/~3/KhCQrKz4uTg/
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Tuesday, September 25, 2012
Study Splits Breast Cancer Into Four Treatable Types
For decades, breast cancer was considered a single disease. Recent research, however, suggested it was a number of genetically distinct variations?and now a new study has split the disease into four differently treatable types.
The study, published yesterday in Nature, is the first comprehensive genetic analysis of breast cancer to date. It suggests that four distinct types of the cancer display hallmark genetic changes, that in the future will be targeted by different treatments.
Part of a project called the Cancer Genome Atlas, designed to build comprehensive maps of genetic changes in common cancers, the study included analysis of tumors from 825 patients. While the researchers found at least 40 genetic alterations that might be attacked by drugs, four of the genetic effects are fundamentally different between the four identified cancer types. Joe Gray, a genetic expert at Oregon Health & Science University, told the New York Times:
"We now have a good view of what goes wrong in breast cancer. We haven't had that before."
Amazingly, the finding offers some immediate implications. The results suggest that routine treatments often used in ovarian cancer could instead be applied to some breast cancers. As ever, though, it's best not to get too over-excited by the finding: while ground-breaking, the finding acts as more of a starting point.
Indeed, the researchers are keen to point out that it will take years to translate some of the new findings into safe, targeted treatments, especially given that individual cancerous tumors of the same type can vary so much case-to-case. But in the longer term, the finding opens up the possibility of diagnosis made on the back of genetic analysis, and tailored treatments plans of drugs and other therapies. The sooner, the better. [Nature via New York Times]
Image by Piotr Marcinsk/Shutterstock
Source: http://gizmodo.com/5945786/study-splits-breast-cancer-into-four-treatable-types
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Do only geeks run internet business marketing? | Tongshu Articles
Do only geeks run internet business marketing?
Author (thirtygrandamonth42). Submitted on Mon, 24 Sep 2012
Do only geeks run internet business marketing ? or can anyone make money this way? How much technical expertise do you need to have a best internet business?
The good news is that you need very little technical knowledge in order to make money very successfully running a business on the internet. Obviously you need to have the basic computer skills. But then you can go to the experts who will help you get started. Don?t try and take short cuts with your website: it will pay handsomely to go to a website expert to get your site well designed and user-friendly. After all, people surfing the web tend to be impatient: they want the sites they visit to be easy to use, they want quick responses to their clicks, and they want everything on the site to work properly. Nothing puts a potential client off an online business like a link that does not do what it is meant to do.
You can also get the experts to give you guidance about optimizing your site for the search engines to find easily. After all, if you want to make money with your internet business, the search engines have to bring it up quickly, as one of the first sites on the page when your potential clients make an enquiry. If your site only appears on page 23 of a Google or Bing search, your customers won?t even be aware that your business exists.
These days the most amazing things are sold and bought via best internet businesses, and new kinds of businesses are also arising simply because the internet is there and giving us the convenience of doing business in new ways. So, even if your previous skills and interests are very far removed from computers and the internet, you can still make money from an online business. You can get ideas for businesses by going online and researching the types of such businesses that exist. Or you can just sit and daydream about the tasks you are familiar with and the things that interest you and thinking ?No, wouldn?t it be nice if?? You never know: you might just find a niche market in which you could operate. Before you know it you could be making money from your own internet business.
After all, it is much nicer to be your own boss and benefit fully from the money that you make than to work for somebody else and have to accept the salary that he gives you. Your internet business marketing can allow you to work in a field you find interesting and stimulating and at the same time earn you money. When you need some technical help there are plenty of geeks out there who will happily help and advise you: many of them are running their own best internet businesses in order to earn money, so look upon your plea for assistance as a great opportunity for them. There is no need to feel embarrassed about asking them to fix a problem for you: they are only too please to do so.
?
About the Author
I live in sunny Sydney, Australia. I have been involved with internet business marketing for a number of years. Even if you have limited computer skills you can make money from small internet business with technical skills to help you get going.
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Source: http://www.tongshu.net/business/do-only-geeks-run-internet-business-marketing.html
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Monday, September 24, 2012
Turkish court hears final arguments in military coup trial
A Turkish court heard final arguments Thursday in the trial of hundreds of active and retired military officers accused of plotting to overthrow the Islamic-rooted government.
The two-year-long case is wrapping up at the court in Silivri, near Istanbul, which heard the final testimonies of the suspects in the so-called "Sledgehammer" trial, named after a 2003 military exercise.
Prosecutors have demanded up to 20 years in prison for the 365 military officers in the case, which concerns alleged army plans to bomb historic mosques in Istanbul and spark conflict with neighbouring Greece to facilitate a military coup.
The defendants argue that the alleged plot was a military exercise regularly held by the army, and question the authenticity of some documents presented as evidence.
A final verdict was expected later Thursday, the first from a series of cases targeting the army.
The trial, which began in December 2010, stands out in Turkish politics because it directly attacks the secular army, once untouchable in the predominantly Muslim country, where it authored four coups in half a century.
At Thursday's hearing, the judge listened to the defence of Cetin Dogan, former commander of the First Army and suspected of being the "mastermind" behind the 2003 plan to drive the ruling Justice and Development Party (AKP) from power.
"Here we see a process unfolding to make the soldiers of Mustafa Kemal (Ataturk, the founder of modern Turkey), who give their lives for their country, to pay the price of their commitment to the Republic and its principles," said the ex-general, according to the written transcript of his defence.
Dogan branded the trial as "unfair and unlawful," claiming it had been launched by supporters with "a mentality considering all those who do not belong to their brotherhood as enemies."
His remarks will likely be seen as an implicit reference to the AKP government and the influence on the judiciary of Islamic cleric Fethullah Gulen's religious movement.
Around 250 of the defendants are standing trial under arrest.
All the defendants have denied the charges and branded evidence as fabricated. Their lawyers were absent from the courtroom in a protest against what they dubbed a lack of willingness on the part of the court to verify the authenticity of documents presented.
"The verdict given will not be lawful but political. We are the victims of a settlement with the army," said General Bilgin Balanli.
Hundreds of suspects, including army officers, journalists and lawmakers, are being tried separately over their alleged role in plotting to topple the Islamic-rooted government.
Pro-government circles have praised the trial as a step toward democracy, but pro-secular ones have branded it a witch-hunt to silence opposition.
The coup trials are also seen as part of an effort by the current AKP government to roll back the military's influence in politics.
The Turkish army, which sees itself as the guarantor of Turkey's secular principles, overthrew three governments in 1960, 1971 and 1980.
And in 1997, it pressured an Islamic-leaning prime minister, Necmettin Erbakan, to step down. Erbakan was the political mentor of current Prime Minister Recep Tayyip Erdogan.
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Cheap, Portable Ultrasound Could a Be Lifesaver .
And that's the "buy now" price for the "Interson SeeMore USB Portable Ultrasound Abdominal Probe". [bonmil.com]
On the other hand...
As someone who had 3 different ultrasound diagnoses, to the same heart condition, by 2 specialists - which in the end turned out to be of viral origin (they were literally chasing shadows); and who later had a dubious privilege of fixing and editing hundreds of ultrasound photos for an ultrasound textbook, with each step done according to the instructions of an instructor/teacher with some 40 years in the ultrasound diagnostic - price of the equipment is not the biggest obstacle in getting the ultrasound "to the masses".
It's training and experience.
And you need literally years of both to start making your ultrasound guesses educated.
Cause without both extensive training with an experienced ultrasound technician AND years of experience in doing ultrasounds of that particular section of human body - that whole "subjective interpretation of an objective method" thing amounts to just guessing.
There's an episode of House [wikia.com] where this is nicely demonstrated by House and Wilson trying to figure out if Cuddy's daughter has swallowed a coin.
On ultrasound it might be a dime, or it may just be an air bubble.
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Students urge GW to focus on business ethics
A campus organization that officially formed Friday is asking the University to examine its contracts and purchases from companies that students say have ties to forced labor and trafficked children.
Free Project at GW, which includes six students, wants the University to become a ?global leader? against what they call slavery, pointing out that everything from food sold on campus to clothing sold in the bookstore could be produced in unsafe or unjust labor conditions.
The group has created an online petition, which gathered more than 400 signatures as of Sunday, demanding that the University becomes more conscious of potential instances of workers? rights violations. Melissa Arndorfer, who leads the group, said she hopes the petition, which went live in August, will hit 5,000 signatures by the end of December.
Lorena Martinez, a senior and a founding member of the group, said she thinks the University can realistically fulfill the group?s demands by taking ?baby steps.?
?It?s not going to happen overnight. We need to engage the entire University,? Martinez said, adding that she?s optimistic that GW will respond positively. Group members said they will officially present the petition to University President Steven Knapp after the petition gains more ground.
Arndorfer said the University should promote ethical purchases by learning more about its suppliers, looking at worker?s pay and fair trade certification to determine whether to take their business elsewhere.
?It?s the food I eat, the coffee I drink every day so I can wake up and go to class. My jeans, leather. It?s all these things,? Arndorfer said, citing her daily encounters with what she calls slavery.
The international affairs major said her group is not trying to ?antagonize? the University, but rather that it wants to set a new standard for the products and services offered at GW.
University spokeswoman Candace Smith said GW ?is committed to conducting its business affairs in a socially responsible manner.? She pointed out that GW is one of about 180 universities affiliated with the Worker Rights Consortium, which requires the University to verify that any official products that bear the school?s logo are checked to ensure ethical production.
Arndorfer said the group plans to raise awareness by handing out promotional material and using social media.
The catalyst for their campaign came from professor Michele Clark?s ?Human Trafficking? class in the Elliott School of International Affairs.
Clark, an expert in the issue, also helped Arndorfer create the petition.
?The cumulative value of this makes people really think about ethical purchasing, and it begins to trickle up [to the companies],? Clark said.
She said another examples of exploitation on campus are the adults she has seen supervising children a they sell candy around the Foggy Bottom metro stop. She said she believes it is an instance of child begging rings.
Clark said the University should call a human trafficking hotline and force the groups off campus to send a message that GW is not tolerant of human rights abuses.
?This should not be a welcome place for them,? Clark said.
Source: http://www.gwhatchet.com/2012/09/24/students-urge-gw-to-focus-on-business-ethics/
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